Involvement of the Soluble Guanylate Cyclase, Nitric Oxide Synthase and Cytokines Pathway in the Anti-inflammatory Profile of N-acylhydrazone Derivatives (JR19)

PR Da Silva, N de Melo Apolinário, SÂS Da Silva… - 2023 - preprints.org
… air pouch test and an assessment of the antinociceptive profile … the involvement of the
nitric oxide pathway and cytokine … , which acts through the nitric oxide pathway and cytokine …

[HTML][HTML] Anti-Inflammatory Activity of N′-(3-(1H-indol-3-yl)benzylidene)-2-cyanoacetohydrazide Derivative via sGC-NO/Cytokine Pathway

PR da Silva, NM Apolinário, SÂS Silva, MEC Araruna… - Pharmaceuticals, 2023 - mdpi.com
test and an assessment of the antinociceptivenitric oxide synthase (NOS) enzymes:
neuronal (nNOS), endothelial (eNOS), or inducible (iNOS). These enzymes facilitate NO synthesis

[HTML][HTML] Exploring the molecular pathways and therapeutic implications of angiogenesis in neuropathic pain

A Sharma, T Behl, L Sharma, OP Shah, S Yadav… - Biomedicine & …, 2023 - Elsevier
… of nitric oxide synthase, and it acts as a central controller of vasodilation [104]. Diabetes
reduce the expression of nitric oxide synthase in … Sprouting angiogenesis is a hypoxia induced

[HTML][HTML] Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells

L Jing, R Gao, J Zhang… - BMC …, 2021 - bmccomplementmedtherapies …
… actions, such as antiinflammatory, antinociceptive and neuroprotective activity, etc., all which
… flavonoids exhibit excellent protective effects on hypoxia-induced failure. For example, rutin …

Molecular insights on the therapeutic effect of selected flavonoids on diabetic neuropathy

PM Sivakumar, PK Prabhakar, S Cetinel… - Mini Reviews in …, 2022 - ingentaconnect.com
… nitrotyrosine levels and inducible nitric oxide synthase (iNOS) … plays an important role in
chrysin-induced antinociception. … ameliorating hypobaric hypoxia-induced memory deficit and …

[HTML][HTML] Second generation of antiepileptic drugs and oxidative stress

K Kośmider, M Kamieniak, SJ Czuczwar… - International Journal of …, 2023 - mdpi.com
… , advanced oxidation protein products (AOPP, marker of protein oxidation), nitric oxide (NO) …
to hyperbaric oxygen (HBO2). Such disorders may occur in divers or in patients treated with …

Recent advances regarding the molecular mechanisms of triterpenic acids: A review (part I)

M Mioc, A Milan, D Malița, A Mioc, A Prodea… - International Journal of …, 2022 - mdpi.com
… the expression of neuronal nitric oxide synthase while the up-… The antinociceptive effect of
OA was significantly reduced in … , UA counteracts hypobaric hypoxia-induced skeletal muscle …

[HTML][HTML] Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications

S Josifovska, S Panov, N Hadzi-Petrushev, V Mitrokhin… - Molecules, 2023 - mdpi.com
… /6 mouse model induced by acute hypobaric hypoxia, discovered that THC … with various
mechanisms, including antinociceptive, anti-inflammatory, … iNOS Inducible nitric oxide synthase

[HTML][HTML] H2S Donors and Their Use in Medicinal Chemistry

E Magli, E Perissutti, V Santagada, G Caliendo… - Biomolecules, 2021 - mdpi.com
… H 2 S regulates systemic and renal blood flow, the amount of glomerular filtration, and the
renin–angiotensin axis by direct inhibition of nitric oxide synthesis. In addition, H 2 S affects …

… Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons

J Zhao, D Liang, T Xie, J Qiang, Q Sun, L Yang… - Neurochemical …, 2023 - Springer
… On the one hand, nicorandil is a nitrite that can produce nitric oxide (NO), activate guanylate
Nitric oxide is a neuromodulator that is involved in different biological functions of the …